WI: No Kushan Empire

Between 30 and 375 CE, a significant portion of Asia* were under the control of the Kushan Empire. What if this empire was never founded? What kind of historical impact would this have?

* I wanted to just say South Asia, but the Kushan Empire also held significant territory in Central and East Asia.


I know Berserk jokes are gonna be pretty much inevitable, so I'm not even gonna try to stop them from happening.
 
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