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Heraclius was emperor at a crucial point in Byzantine history. He suceeded in reconquering most of the territory lost to the Sassanids but was unable to stop the Muslims when they began their conquests.
So WI he never rebels against Phocas? Do the Sassanids retain control of Syria, Egypt etc? Are they more or less successful than the Byzantines against the Muslims? What happens to the Byzantines in a few years?
I'm going to make a (probably way wrong) prediction. I'm going to say that the Sassanids will be too weak to hold off the Muslims, but I'm thinking their Eastern terrtories could survive for longer. As for the Byzantines, I'm not really sure. (Although I love the Byzantines, I'd also love to see a TL with them falling in the inital Muslim onslaught...)