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What if Carthage simply didn't exist? The Phoceanian traders and Dido (first queen of Carthage) didn't build Carthage or settle that area of North Africa (modern day Tunisia).
What would the effects on the Mediterranean be without a Carthaginian trade power? Could a Rome as we know it even exist without a major power to challenge it early on? Would North Africa and Sicily even ever be conquered by Rome without a Carthage? What would be the effects on the Hellenistic Kingdoms without a Carthage rivalry? Etc.