The main problem with that is the Amerinds kept dieing from all of the diseases that the Europeans brought with them.
Using them as slaves/serfs were only really possible where there were a lot of them, i.e. in Mexico and Peru (Aztecs and Incas respectively).
Secondary problem was the Indians getting loose and massacring all Europeans they could, before escaping back into the Forest.
Not the best for Labor relations.
After realizing that the Indian Slaves wouldn't work Large scale [thro there were Indian slaves as late as the 1800's in Canada] Europe turned to it's prisons.
It is said that King James ran one of the only prison systems to make a profit.
The Dutch in New Amsterdam tried turning it's transportees into Serfs.
It wasn't till 1848 that New York Repealed the Serf Laws, Thro the practice had died long before.
The main problem was it was illegal to main, someone, as a ID, So the Transportees would escape westward, and claim to be recent immigrants.
If they got far enuff away, their "Owners" had no way of ID-ing and compelling their return.
Negros OTOH had a built in ID marker.
There is also the problem that the Africans brought with them Knowledge about, certain Crops.
It was slaves from East Africa for example that taught the English in the Carolina's how, to grow Rice.
Without this, some crops would be much less likely to be developed in the Americas.
Whe also have the Fact that in the early 1500's most African Slaves were imported into Europe, to replace the vanishing Serfs.
Without this whe have much less wealthy Portugal, with associated Butterflies.
So whe need a POD before the 1450's, and need this to continue till the 1800's, and the industrial revolution.