The 80s and early 90s might be less uptight without it. With AIDs, there was an issue of this moral dictation of what to do, and something to back it up. Without it, there's the dictation of that Reaganite era, but who cares.
Just in the real of sex specifically, AIDs put a huge stop on liberated sex that had come up in the 60s and 70s. It used to be whatever you got was cured by a penicillin shot, so the only thing people were worried about was pregnancy, and that was fixed by the pill. Sex became mainstream, and sex became decadent with many people. The kids banged whatever they could whenever they could, the adults had key parties and swinging. AIDs made that go bye-bye. And back to non-sex, it put a stop to a lot of fun/decadent activities by making them more dangerous since sex was usually part of the evening or blood transfer via needles, and where they didn't stop, they took casualties. AIDs was a cold bucket of water on an era of liberation and of more permitted decadence.