If Burgundians adopt Lutheranism when (and if) Reformation breaks out Pope would have a severe headache by having a Lutheran state above his own borders... Maybe Popes try and incite a Crusade against Burgundy in such a case...
Burgundy is no closer to the Papal States than north Germany, and surely no more threatening than the other Protestant states, surely? I think by the 1500s the Crusade was essentially outdated as a Papal tool anyway. A couple of Popes tried it, and the Battle of Lepanto was a good victory for Christendom v Islam, but by this point Kings weren't really interested in committing troops to a Crusade. I'm not sure the Pope would try it for the reason of expected failure of raising a decent army.