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What might have happened if Louis XII's daughters were to have died before him? Claude of France was a rather delicate girl and could have succumbed to her own ill health at some point before her marriage to Francois d'Angouleme. Renee of France herself while stronger than her sister could have died in her infancy of a childhood illness.
If Louis XII were to die without heirs as OTL there'd be no one to inherit the French throne from the main branch of the family. And without his daughters he can't ease the way for Francois d'Angouleme's ascension to the French throne through marriage to his eldest.
Just how much of a quandary would the French have been in at this time?