WI: Lorenzo II de Medici, Duke of Urbino Survives

Lorenzo de Piero de Medici, duke of Urbino died on May 4 1519 - more or less alongside his wife (28 April) - of an unspecified cause (although hers may have been childbed fever).

What happens if Lorenzo were to recover? His uncle (Giuliano de Lorenzo) had died only three years before, so for Lorenzo to become the newest pawn in French interests in Italy (like the Borgias in the previous generation) doesn't seem completely impossible. Would he fare better than Cesare Borgia did, though, and manage to create a lasting state - whether Urbino or Florence or some union between the two?
 
Would it be wrong to assume that Leo X/Clement VII would use their nephew/cousin in order to try organize a similar state in central Italy as what Alexander VI tried with Cesare? Or would Lorenzo be still more a bauble that hung from the French king's belt than what Cesare was? Who might he remarry to?
 
Another question, might Lorenzo be granted his late uncle's dukedom of Nemours? OTL Giuliano's widow, Filiberta of Savoy seems to have held it until her death.

Here, might Lorenzo be acknowledged as heir? Maybe even be married to the widowed Filiberta?
 
If both Lorenzo and his wife survived plague then Medici would become Princes Étrangers as heirs of Auvergne even without Nemours, also, if they have any sons, then Catherine, not being heiress of her mother's lands, would not marry Henri de Valois.
 
If both Lorenzo and his wife survived plague then Medici would become Princes Étrangers as heirs of Auvergne even without Nemours, also, if they have any sons, then Catherine, not being heiress of her mother's lands, would not marry Henri de Valois.

Well, the idea is that Madeleine still dies (if her death was childbirth related) while Lorenzo pulls through. A remarriage between Lorenzo and Louise Borgia could be funny, although I doubt such a marriage would be likely.

That said, had Madeleine survived, it would certainly diminish Caterina's prospects. Unless Caterina's birth damaged her mother so that there is no possibility of a brother. And even then, having an uncle who's the pope might make an annulment a matter of form (look at the speed which Lucrezia Borgia cycled through husbands)
 
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