The Nazis were happy to have high profile Jews leave - it allowed them to put a somewhat better face internationally on their internal policies. As long as the Jews left the bulk of their property behind, getting Germany to issue an exit visa was not an issue. The problem was getting ANYONE to give them an entry visa (cf: SS St Louis). Once the Germans had decided on extermination as a policy, building on the Einsatzgruppen, random atrocities, and culling by disease and starvation, they made very little use of the talents of their Jewish prisoners. The currency forgery operation was an exception to this and involved very few individuals. Given Hitler's rants about atomic physics being a "Jewish Science", I can't see any of those who left Germany after 1933 convincing the Nazis to put more effort in to the atomic program, or convincing Heisenberg that the amount of fissile material needed for an explosion was in the range of 10s of kilograms, not hundreds or more. Even with the fate of their families being held over their heads, I can't see Jewish scientists forced to work for the Nazis pushing advances that their Aryan fellow scientists have overlooked - why push to convince Heisenberg that atomic weapons are practical, just go along and agree with his estimates.
I can't be sure without a lot of checking, but it is my impression that the leading Jewish scientists from Europe including Germany left fairly early on, and by the late 1930s most had left, most even before the Nuremburg laws. In the first few years of the Nazi regime Jews were pushed out of university positions and government funded institutes rather rapidly, and these folks left for greener (and safer) pastures as soon as possible. Don't forget that other Jewish scientists and highly educated folks left other continental countries where anti-Semitic laws and restrictions on employment were passed during the late 20s and 30s.