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IOTL Leo Szilard served in the Austro-Hungarian Army in WWI. What if he'd been killed in action?
Who else is likely to come up with nuclear chain-reaction theory? Someone surely will within a few years of OTL. Who are good candidates, and when do they come up with it?
There probably won't be an "Einstein letter" to FDR without Szilard to author it. When does the US start the Manhattan Project - does it spin off Tube Alloys sometime in 1942-1943? When will the first a-bomb be ready?