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Been perusing through the history of the First Fitna within the Islamic community and came across some of the happenings around the murder of Caliph Ali ibn Abi-Talib. Apparently the radical sect responsible for the deed, had also planned for the death of Mu'awiya (the eventual first Umayyad Caliph) and Aisha (widow of Prophet Muhammed) for the sin of arbitrating the waning civil war with one another (which started after the assassination of Caliph Uthman).
So what if they had succeeded? What would the simultaneous deaths of three major figures in early Islam have on the Caliphate?