WI: Juana of Castile marries Edward, Prince of Wales?

This possibility came up in my planning thread for a Yorkist TL I've been hashing out for a while, and I couldn't resist exploring it, even if it isn't actually used in the TL.

Anyway, what if Edward IV manages to wed Edward, Prince of Wales with Juana of Castile, daughter (and unexpected heiress) of Ferdinand and Isabella? We'll say Anne of Brittany marries Richard of Shrewsbury just to tie up that loose end. If Edward lives to succeed his father and in-laws, how would this personal union of England and Spain work out? What are the consequences going forward?
 
This possibility came up in my planning thread for a Yorkist TL I've been hashing out for a while, and I couldn't resist exploring it, even if it isn't actually used in the TL.

Anyway, what if Edward IV manages to wed Edward, Prince of Wales with Juana of Castile, daughter (and unexpected heiress) of Ferdinand and Isabella? We'll say Anne of Brittany marries Richard of Shrewsbury just to tie up that loose end. If Edward lives to succeed his father and in-laws, how would this personal union of England and Spain work out? What are the consequences going forward?

Why not go for gold and let Edward V marry Isabel (OTL princess of the Asturias)? Richard III was in talks to get her as a bride for his son, Edward of Middleham, when that boy died (and he may have briefly entertained the idea of marrying her himself when Anne Neville soon followed), which shows that in the mid-1480s the idea had legs. Kinda. Plus, given Isabel and Fernando's dislike for the king of Portugal, I could see her almost jumping at the chance. They can use the excuse that Juana or Maria is much closer in age to Affonso than Isabel, and while I could see them having to probably cough up some extra dosh for the inconvenience, I think it could be pretty likely (at least, not ASB unlikely).

As to Juana marrying Edward, it's not a bad idea. The Yorkist court might see a double match Juan to Anne or Katherine of York (Anne's older so she can get to bearing kids quicker for Juan's suspect health) and Edward to Juana. However, I will caution that Henry VII/VIII's playing games with his children's betrothals - seemingly thinking that a theoretical engagement was better than an actual marriage wasn't limited to him alone. Edward IV did the same with his kids, he expected them to make grand matches "with naught but their looks as dowry" (wrote one contemporary). In fact, I could see Fernando and Isabel struggling to wring a dowry out of Edward IV to cover Anne/Katherine's household/expenses long after Isabel/JHuana's dowry has all been spent by the English.
 
Well between Yorkist and Trastamara fecundity, this is going to be one big family. Of course, Juana might find it quite hard to rule Castile from England, which has got to have consequences, even if I'm not sure what those consequences are yet. At least Juana is less likely to end up locked away...
 
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