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In another thread I started days ago, I was considering the possibilities of Joanna of Castile, 'The Mad' and Philip of Burgundy, 'The Handsome', having more sons other than Holy Roman Emperors Charles V and Ferdinand I.

I suggested in the same thread a scenario in which Joanna and Philip fail to produce sons, leaving only daughters (Eleanor, Isabella, Mary and Catherine) as heirs to territories of their grandparents, in other words Castile, Aragon, Burgundy/Netherlands and Austria/Holy Roman Empire. Other option would be switching the gender of Charles and Ferdinand, giving to other daughters to Joanna (let's call them two girls Margaret and Barbara for instance).

Now, this thread approaches exactly this scenario: what if only the Habsburg girls were left to inherit? Surely the effects of such thing would have turned Europe's political scene a lot, lot different. As IOTL, Philip would die in 1506, Ferdinand without male issue in 1516, and the same to Emperor Maximilian three years later.

I was already planning a timeline by my own here, where I would post it already written. However, I've been busy lately and, well, as many of you can see from my previous posts/threads regarding 16th century Europe, my enthusiasm about this period and my actual knowledge about it mismatch so some degree, so I'd like to ask for your help to know what would've happened.

How would've foreign policy developed? How about Spanish colonization? Would the inheritance be split amongst the girls? Would events as the Sack of Rome and the Dutch Revolt have happened? Who would marry the girls in order to strenghten their position as rightful monarchs to the Trastámara-Habsburg-Valois territories?

I'd really appreciate your help and ideas to stretch it the further we can! :)
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