WI Joanna la Beltaneja is never born

Exactly what the title says. If Joanna la Beltraneja was never born, avoiding all the War of Castillian Succession, how would it affect the Iberian kingdoms? Assuming that Alfonso - the half-brother of Henry of Castile -still dies in 1468 then Isabella becomes the only heir of the throne, but ITTL she wouldn't need a war to get it. Would she still marry Ferdinand of Aragon?
 
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