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What if Isabella of Aragon, Queen of Portugal survives the birth her son Miguel da Paz, but was rendered infertile. Miguel still dies in the summer of 1500. (He was born sickly) Lets say Isabella lives to 1533. What happens to the Portuguese succession after Manuel I of Portugal's death? Who does Maria of Aragon marry? There was talk of her marrying James IV of Scotland. What happens to the Holy Roman Empire with a surviving Philip the Handsome? What would the ramifications be with this POD for Europe and the World? Please discuss!