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In a scenario where Edward IV lives a bit longer and the Prince of Wales is still betrothed to Anne of Brittany, it seems a war with France is pretty likely. A Brittany in personal union with England is unacceptable to France, making war likely. How would this conflict likely go, does this lead to a series of wars between England and France in lieu of the Italian Wars, how will the rest of Europe be affected.
All credit goes to @Zulfurium for suggesting this.