In 2000, Nita Lowey would likely be the Democratic nominee for Senate. Lacking Clinton's success upstate, Lowey could lose to Rick Lazio, which would give the Republican party a one-seat majority in the Senate. You might also have some interesting butterflies in the Presidential election if Hillary Clinton serves in place of her husband as a campaign-trail surrogate. Assuming George Bush wins the 2000 election and his administration progresses essentially the same as OTL, John Edwards is probably the front-runner going into the 2008 Democratic primaries, but is unlikely to actually win the nomination due to his vote for the Iraq War and his personal indiscretions. Obama ends up winning the primaries more decisively than IOTL. Mrs. Clinton, by now a respected elder stateswoman, is the subject of uninformed speculation for the Vice Presidential nomination, and later a cabinet or Supreme Court seat, but prefers to retain her leadership role at the Clinton Foundation and several corporate boards. Obama selects either John Kerry or Chuck Hagel as his first-term Secretary of State. In 2016, Obama's Vice President (most likely Biden, but an easier primary could lead him to go for a more daring pick like Sebelius or Richardson) gets the nomination with only token primary opposition. The outcome of the general election depends on the Republican nominee, which is subject to too many butterflies for me to predict.