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While reading about Charles de Valois, Duke of Orléans, I've found this information:

"In the autumn of 1545, Charles was on his way (with his brother, the Dauphin) to Boulogne, which was under siege. On 6 September, they came across a cluster of houses that had been emptied and sealed off "from the plague" -- probably a form of influenza. Stating that "no son of a King of France ever died of plague", Charles entered some of the infected houses with his brother [3]. Laughing, he slashed at bedding with his sword and started a pillow fight with some of his traveling companions. Stories have also been told of him (on a dare) lying down on one of the infected beds and rolling around on the bedding. Later that evening, after dining with his father and brother, he took suddenly ill, suffering from pain, a high fever, vomiting and shaking limbs. His brother rushed to his sickroom immediately, but was barred from entering, being physically restrained on three occasions."

So, as Henry entered the infected houses too, WI he had died from this illness along with Charles? His son Francis II was already born, being only one year old, but then Charles IX, Henry III and François, Duke of Anjou, wouldn't exist ITTL. How could it affect France?
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