http://en.wikipedia.org/wiki/Joanna_la_BeltranejaAt the death of Isabella in 1504, Ferdinand is alleged to have proposed to her to keep the throne from his son-in-law, but she refused.
What if La Beltraneja accepted this proposal and Ferdinand was able to sire Children with La Beltraneja?, any children of Isabella might be sidelined and the children of Juana la loca can not inherit anything on Spain.
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