His first wife, Luisa Maria Gabriella of Savoy, died at the age of 26, after giving birth to four children. The Spanish loved her, nicknaming her 'la Saboyana', and she was rumored to be the real power at court, dominating her husband who was madly in love with her.
What if she had lived? Of course, it removes Isabel Farnese from the Spanish scene, but I feel it also alters the entire future of Spain, since none of her children left issue.
Discuss.