POD: FDR is assassinated, just before his inauguration in 1933. In OTL, there was a real assassination attempt (by a deranged bricklayer) which killed several people but not FDR.
Result: the Vice President-Elect, John Nance Garner, becomes President in March 1933.
Anyone have any thoughts on the consequences of Garner replacing FDR? Now, I assume that Garner would win two terms and that Wendell Wilkie would win the 1940 Elections against Democrat [insert name here]. But who would be Garner and Wilkie's VP? What about World War II?