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In her hour of triumph, Elizabeth was in a weak state. She may have caught an infection during parturition, as she is recorded as suffering ague - an acute fever - during her lying in period.
Elizabeth of York: The First Tudor Queen by Alison Weir (Chap. 9, Pg. 229)

Elizabeth's ague persisted into autumn. Her prolonged ill health after the birth of Prince Arthur may have been the reason why she did not conceive another child for nearly two and a half years.
Elizabeth of York: The First Tudor Queen by Alison Weir (Chap. 9, Pg. 236)

Basic Scenario: Elizabeth of York, in the months after Arthur Tudor, Prince of Wales, is born, succumbs to the illness that she seems to have had and thus dies at the age of 20, leaving Henry VII of England a widower as a new King.

Main Questions:
  1. What are the immediate reactions of both England and the rest of Europe?
  2. Who does Henry VII of England marry in the wake of her death? Does he marry one of her sisters or, with the half York son he already has, does he look for foreign prestige? *
  3. How does this effect England in the wake of pretenders ala Lambert Simnel and Perkin Warbeck?
  4. Without the calming influence and domestic happiness of his wife, does Henry VII of England have a more aggressive/worse image than OTL?
  5. If he does marry a non-Yorkist Princess, then what are the consequences when Prince Arthur dies in 1501?
*One thing I should add to this question is that Henry VII was formally recognised as King in his own right and was granted that confirmation by the Pope that he owed his throne to himself and not his bride. Thus, it could be said that he makes his own claim weaker if he remarries to either Cecily or Anne of York, because that action would be paramount to saying he needs the Yorkist marriage to justify his own dynasty. In saying that, the Yorkist marriage is what legitimized him to many in England, but by this point there was no other major players to fight against.
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