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IOTL, Edward Longshanks, the future King Edward I of England, was attacked by an assassin. Edward killed the assassin, but was struck in the arm by a dagger, which was feared to be poisoned. What if the assassin had aimed a little higher and managed to wound Edward in the neck, or the blade had been poisoned and Edward lingers before dying in the Holy Land?
The next in line for the throne would by Edward and Eleanor of Castile's son, Henry. Although news of Edward's death would probably take some time to reach England. Assuming Henry IV* still falls ill and dies in 1274, would the next in line have been his sister, Eleanor (https://en.wikipedia.org/wiki/Eleanor_of_England,_Countess_of_Bar), or his uncle, Edmund Crouchback?
What other wider consequences would have occurred? Wales may continue to be independent and a thorn in England's side.