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Instead of Old World diseases laying the New World populations low OTL, what if the following occurred instead?

The Americas have their own virulent strains that natives have adapted to, but the Old World has no resistance. Also a possible resistance to Old World diseases (e.g., smallpox), so those effects are lessened or minimized?

This could cripple the colonization of the Americas, but more so, if the diseases are brought back to the Old World, would further exploration be forbidden?

Ric350
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