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Okay so hear me out: What if, instead of moving to far-off Byzantium, Constantine decides to hold court in Sicily, making the already-rich Palermo his capital?

While he wouldn't have the sheer defensibility of OTL Constantinople, Palermo was a large grain producer if I remember correctly, and was fairly to close to Egypt, the other grain producer.

Plus, Sicily is close to Rome, so Constantine could claim that he had not abandoned it.

So what would cause Constantine to look torwards Palermo instead of Byzantium? A plague, a mass rebellion, etc?
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