Short answer : no.
Long answer : He wasn't even able to really hold power in Rome to begin with, trying to create a podestate as it was the custom in italian city-states, and his success as revolt leader made him really quickly have desillusion of grandeurs (such as claiming to be the illegitimate son of Henri VII).
Not only mentally unstable, he didn't had access to a real military power, nobles being still a strong opponent faction with their clientele, to efficiently fight his opponents let alone a military power able to take on HRE.
He's the protoype of italian populist, as with Savonarole, whom ambitions and objectives were too much out of touch with reality, and eventually rejected by the people that put him in power.