Dude, Burgundian-led kleindeutsche Lösung FTW!
No, not really. But a stable Burgundian dynasty will have efects on France and Germany that will reverberate for quite a while. Likely, Burgundy will dominate the Rhineland, maybe even swallow it up. If the state survives into the 17th c, French expansion is liable to focus more on Italy and the Pyrenees. Also, no sense of Habsburg encirclement might head off the very aggressive foreign policy of Louis XIV (or not - the guy was a bully anyway). For that matter, the fact that Burgundy would end up having the spiritual electors under its thumb might shift power inside the HRE. A Reformation in Burgundy could have extra special repercussions in that light, though if Burgundy does *not* go Reformed, there is a better than even chance the Dutch territories will revolt.
Best-case scenario in terms of coolness: A Reformed, militarily powerfgul and economically booming Burgundy centered around the Rhineland and Netherlands, majority 'Dutch'-speaking (there used to be a fairly constant dialect cline into Westphalia), and, with control of the votes of the electors spiritual, claiming the imperial crown.
With colonies in the Americas. And trade posts in Africa and India. And controlling the East Indies trade. Foer Christum en de Loeew! Hurrah Borgund!