Archduke Charles (1540-1590), son of Holy Roman Emperor Ferdinand I, may not be that important himself, but his descendants played important role in history-Charles was father of Holy Roman Emperor, Queen of Spain and two Queens of Poland. So what happens if he is either childless or none of his kids survives childhood? His nephews, sons of Maximilian II, would certainly benefit rom his childless death. As Styria and Tyrol were ruled by Maximilian II's brothers, Max had no territory which he could give to younger sons, now at least Styria is available (most likely for Ernst). As Archduke of Styria Ernst could marry earlier, so as side effect Maximilian II's line may survive. Meanwhile what happens in Spain, when there is no Habsburg princess available for Felipe III? Perhaps princess from Lorraine as French proxy?
Poland would be less problematic. As there are no Habsburg princesses available Sigismund Vasa would, like his father wanted and his sister urged him to do, marry Christina of Holstein, OTL wife of his uncle Charles and mother of Gustav II Adolf. Protestant wife may help him to keep Swedish throne (not that such change alone would guarantee that he'd remain on the throne, but it would certainly help a bit). What other changes should happen?
Poland would be less problematic. As there are no Habsburg princesses available Sigismund Vasa would, like his father wanted and his sister urged him to do, marry Christina of Holstein, OTL wife of his uncle Charles and mother of Gustav II Adolf. Protestant wife may help him to keep Swedish throne (not that such change alone would guarantee that he'd remain on the throne, but it would certainly help a bit). What other changes should happen?