The other Savoyard thread reminded me that - if he doesn't have an heir from his 2nd wife - Charles II of Savoy would have died heirless, too.
This could easily have happened if he hadn't resisted le Grande Mademoiselle's advances once his first wife died - she was willing to accept marrying him despite her being in her upper 30s, but he refused.
If he marries her figuring she can have an heir (r he has a child who survives just long enough for him to marry her thinking he doesn't have to worry) it sets up an interesting situation.
Louis XIV could try to take Savoy for France - it would then include Piedmont, too, I believe - through Christene of France. Chalres Emmanuel also had a sister who was the wife of Ferdinand Maria of Bavaria, too, so one of those issue could also have taken; perhaps his son who became Bishop of Cologne takes the crown instead? Or, do Louis XIV and his Barvarian allies afree that Louis will take Savoy and the Wittlesbachs Piedmont? It'd be interesting to see who then can unite Italy in another couple centuries; thinking of them as German it would be funny to see Wittelsabch Italy.