WI: Charles and Buckingham die in Spain

So, what if Prince Charles and George Villiers Duke of Buckingham die of illness during their trip to Spain in 1623?

Does this break James I?

The new heir is presumably James' last surviving child, Elizabeth, who is presently in exile in The Hague after being driven out of the Palatinate in the early stages of the Thirty Years War.

There'd also likely be rumours abounding about how the vile Spanish papists poisoned Prince Charles, which could have foreign policy implications if people get worked up into a clamour.
 
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