I know this has been hashed out, but I don't want to really spend too much time on the PoD itself, but more it's consequences---particularly, the long-term political consequences of a united Middle Kingdom of 'Burgundia' or some similar moniker.
The PoD has to be such that Charles the Bold is granted a king-level title by the Pope with the Emperor's consent (this was in the works---if only Charles had given back Alsace, he might have gotten his crown), such that the marrying-off of a female heir would not spell dissolution for the mish-mash of titles that was the Duchy of Burgundy at the height of its power in the 1470s.
Once the crown and succession are secured, Charles patches relations hastily with the Emperor, perhaps even formally swearing fealty (but still remaining mostly independent), which would probably touch off a war between France and an Imperial coalition, led by Charles. France is defeated and the French claim to Burgundy is rescinded, allowing Charles (and his heirs) the necessary time to consolidate and centralize the ethnically, culturally, and eventually religiously very diverse lands of the new Kingdom of Burgundy/-ia.
Immediate consequences:
-France is weakened, possibly forced to pay reparations; this affects the future of French ambitions on the continent, as the Lowlands are no longer a ripe and juicy target for expansion (possibilities include a quicker integration of Brittany, successful conquest of Naples by Charles VIII, stronger/more successful invasion of Italy, France goes colonial sooner, resists Reformation due to Burgundy serving as buffer/sponge to soak up Protestant influence
-Burgundian-Habsburg relations are initially positive, though quickly sour as it becomes clear that the heirs of Charles share not only his ambition but his sour attitude toward Habsburg hegemony. A number of wars are fought between Burgundy and various Imperial coalitions, both offensive and defensive, over Burgundian expansion in Northern Europe. Burgundy being as wealthy as she was, and only getting wealthier, employs increasing numbers of mercenaries, repels every coalition army, and thus becomes exceedingly proficient at defensive warfare. However, Burgundy's territorial gains in the Germanies are limited and temporary at best.
-The near-constant exposure of Burgundian nobility to mercenary captains on the battlefield leads to greater army integration and forms the foundation for a modern standing army.
The Future:
Here's where it starts to get shaky. I have some ideas, but I'd like some feedback and to get a discussion going, because for some reason this is a burning issue for me. Here's what I think might happen:
-Burgundy goes Lutheran during the Reformation due to increased assimilation of the Lowlands as well as heightened relations with the North German states. Calvinism does not take hold. Relations between the Protestant north and the Catholic south are assuaged when the King himself converts.
-Charles V still inherits Spain from his mother, but never fights the long and costly wars with France that drained his empire to the point of exhaustion, and thus is able to halt Ottoman expansion. Spain and Austria still split between branches of the Habsburg family, but ties remain close. Spain becomes an even greater power due to not having been drained in war after war with France.
-Burgundy goes to bat for the League of Schmalkalden, likely taking a leadership role, as Burgundy has her own political interests to consider within the Empire and beyond. Burgundy likely has had to fend off a number of French invasions, but again, due to their economic advantage is able to weather these wars better than Austria under Charles V did in the early-mid 16th century.
What else can you guys think of? What am I missing? Certainly quite a bit, and I want to explore this and expand on it as I'm able.