But that could potentially but them at odds with the Southern colonists (South of Virginia), no? Since the rest of the Southern colonists would be eyeing Texas and potentially even Cuba as potential areas for expansion.
I think we are way too early for that. Georgia was only partially settled and Florida was where southerners were looking as a buffer state (not even for settlement). Most of the settlement from the south was actually Eastwards via the Cumberland gap into eastern Kentucky and Tennessee. Alabama and beyond would be considered wild Indian country far beyond civilisation for thousands of miles. Texas wouldn't have been considered anywhere near at the time.
Cuba was core Spanish (at the time a major power) and would never have been realistically considered for annexation.