There's this idea a while back on the brief Anglo-Spanish war in late-18th Century Philippines; the Pacific side of the Seven Years War. In 1762, forces from the East India Company managed to occupy Manila until it was returned to Spain at war's end. Suppose they were more successful, and the Brits absorb (most) of the colony to the Empire? I considered additional assistance from London being part of the POD, but how would an Anglicized Pearl of the Orient look like?
As an added note: is a Spanish enclave in the Zambuanga peninsula (Mindanao) possible?