Anne, Duchess of Brittany and twice queen of France was pregnant 14 times, yet for all her trouble, she produced only three children who outlived the year of their birth: a son and two daughters. And the son lost an unfortunate fight with measles.
The premise is simple. Anne succumbs to childbirth fever after Claude is born. And I wonder if it wouldn't have been a tender mercy? I mean being pregnant 14 times is bad enough, but to be pregnant 14 times and eleven of those pregnancies end either in stillbirths or shortlived children. So, at the dawn of the 16th century, Louis XII is now a widower, and his third wife OTL is all of four years old, what does he do? Obviously he'll remarry, and he'd probably end up as regent in Brittany for Claude (IDK if he would, who else was available? The prince of Orange was constable, I think), but betroth her as OTL to the young Comte d'Angoulême (if only to keep Brittany in French royal hands). But who would be offered as queen of France? And what impact might this have on the next decade or so (let's take it to Louis' OTL death date of January 1 1515) of French politics?