1/2. By the time of Constantine the empire was divided culturally between a greek speaking east and a latin speaking west. Furthermore Diocletian's division of the roman empire was similar to Constantines and set a precedent.1) The problem is that as of Constantine, the concept of "the WRE" as a separate polity doesn't exist.
2) See above.
3) If Antioch was the capital, it would likely have been taken in the Last War, with unpleasant consequences.
3. If Antioch had been the capital the Persians would likly not have got as far during the Last War. Also when Constantine was choosing the eastern capital he wouldn't know that the Persians would ever get so far west.
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