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Not quite sure if it would be possible, but thought it would be fun. D. Sebastiao is born as a girl, and for a husband she ends up married to one of Maria of Spain's plethora of sons (not the future emperor). Or D. Sebastiao marries, but only manages to produce a daughter before his death at Ksar el-Kebir. Said daughter marries a younger Habsburg archduke/infante and creates a sideline of the house of Habsburg in Portugal.

Possible? Doable?
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