This is something I've been wondering about since I first found this board. The duc de Guise was sometime head of the shortlived Neapolitan state of the 1640s, and was as much remembered in his own days for his political failures as for his romantic liaisons. Three women were "duped" by him over the course of his life into believing that their "marriage" to him was genuine:
1) Anna Gonzaga (OTL Princess Palatine as wife of Eduard of the Palatinate, a younger brother of Prince Rupert) - whom he supposedly married in 1639, but which Henri himself repudiated.
2) Honorée de Berghes, Comtesse de Bossut (a widow) whom he "married" in 1641. The Rota declared this marriage valid, but Louis XIV refused to sanction it, and declared it "null and void" due to the fact that Henri and Honorée had been living separately since 1643.
3) the least well known of the trio of ladies: Judith de Pons, daughter of the Marquis de la Case and Charlotte de Parthenay, who, having conceived a passion for her, he abandoned Mme de Berghes in 1643.
It was in the midst of the tabloid scandal that was his abandonment of Mme de Berghes (whom the dowager duchesse de Guise - his mother, and grandmother to La Grande Mademoiselle - managed to prevent from coming to France to take up her place at her "husband"s side) that he married Judith de Pons, a lady-in-waiting to Anne of Austria. Anne and the dowager duchesse seem to have been friendly, since Anne sent Mlle de Pons packing. The duc wrote angrily to Anne about the "shabby" treatment of his wife, never mind the fact that the "queen of Naples" (as Judith styled herself) was carrying on with one of the dowager duchesse's equerries. The letters the duc addressed to Anne and Mazarin went unanswered, and Mlle de Pons wound up in the convent of the Filles de Ste-Marie.
So, all things considered, which marriage of the duc de Guise should be the one found to be legitimate? Anna brings political clout - but not much else, unfortunately. Mme de Berghes brings money (which was why de Guise married her, and why she attempted to sue for desertion and the return of her dowry when he jumped to France; adn why the Dowager Duchesse blocked her entry). Not sure what Mlle de Pons brings to the table though