Short answer: nothing good....
Longer answer: Depends on how it looks like. If a full scale armed uprising...well First Nations in Canada are geographically dispersed, more or less isolated from eachother, dependent on the government for housing, food, fuel, and in some cases water on the reserves where the majority live in the 90's. And through the status system the government has a handy dandy guide to literally every single status first nation person in Canada.
So FN populations near population centres are essentially violent riots for a few days in larger cities and a few weeks in smaller ones before local law enforcement/vigilantes swamp the FN with numbers and gain control. Any deaths of FN are ignored by the justice system/police. Areas like Northern Quebec have a bit of negotiating power since they also happen to intersect with Quebecs hydro dams and their isolation makes them difficult to deal with but I can't imagine any federal politician in Canada is going to be in a negotiating mood. Canadians at the best of times are not very sympathetic to FN when there is ANY inconvenience to them. An armed uprising will destroy/drive underground any support FN have among the non-FN population.
So 6 months to a year after it starts FN leaders are dead/in jail/in hiding, Reserves are under occupation, FN are completely ostracized by society at large, and the federal government is getting ready to repeal any part of the constitution that has anything to do with FN nationhood stripping them of any ceded land/rights that have been granted. Canada's international reputation has hit the gutter on account of the near ethnic cleansing in parts of the country and the economy has and continues to take a hit due to periodic blockades and sabotage along isolated sections of highway and railways. So....nothing good