No, no, no... even if the fire is just delayed for a decade or so, this could prove to be a potentially very interesting timeline. Without the great fire, the Old St. Paul Cathedral remains. So sir Christopher Wren is never commissioned to design a new, grander cathedral in its place. No less than 50 other churches will not be constructed by him. Christopher Wren was a skilled mathematician and astronomer, sir Isaac Newton admired the man...
What happens if Christopher Wren is given some more time to stay out in Cambridge? Could he make Newton's discoveries a little earlier?