No but I think the more the most aggressive types harp on this issue, the more they'll be seen as unnecessarily negative. I won't claim to know anything about this woman but unless she's scandal prone I think the American people would move past it eventually.
"Mr. President, do you use the Lincoln bedroom for your out of wedlock trists with the lady who's career has exploded by having her face plastered all over globe? Or do you prefer the Resolute desk?"
I'm not saying that it's objectively important, but to pretend that this wouldn't be an issue in the 1970s is fanciful.