The war had had already driven most whites from frontier settlements and many of the whites in Charleston to ships. What if instead of turning on the visiting Creek and Yamasee at the Tugaloo massacre, the Cherokee decided to join them in burning out Charleston and the remaining English South Carolina settlements?
If the deep south needs to start over from scratch, how does that work out for the region. Is South Carolina vacant of English settlement and authorities until perhaps the English send James Oglethorpe to establish a colony of "Georgia" there?
Do the Spanish or French take advantage in the meantime?