If you took the title at face value, you may get a show that would make more sense in South Africa.
'Star Trek' would have a lot of echoes to the great trek. The *Enterprise (*whatever it would be called atl) would be a scout ship for a fragmented colonization fleet. They left Earth because the Vulcans were taking more authority than they could tolerate.
The human crew would be monoracially white, or include a few indians or chinese (not in dominant positions), the aliens mostly subordinate, analouge of the coloreds that went with every wagon train. The show would be about scouting out the path for the fleet, scouting out new worlds for colonization, bringing civilization and law to new planets of primitives, and battling and matching wits with seemingly ubiquitous Klingons and Romulans.