What happens if William of Jülich-Cleves-Berg was female?

She'd be a likely candidate for Charles V's wife. Assuming he palms off Anne of Bohemia to Ferdinand as per OTL, he might decide possession of Julich-Cleves-Berg is worth more than a Portuguese Infanta's dowry when it becomes clear Mary Tudor isn't coming his way.

Alternatively Henry VIII might look her way when Anne Boleyn falls.
 
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