Rise of Grandee Class who dominated the government, fill government with Nepotism and Incompetence
Rise of limpieza de sangre which froze social structure
Inflation because of gold and silver from New World
Dutch War and Religious War in Germany who exhausted a lot of money.
Opposition from France who fell encircled by Habsburg Domain
too close association with Catholic Church, who cause rebellion in Hungary and Germany and Netherlands.
mismanagement and instability in Italian Pennisula