The TL explores the scenario of the Wettins gaining an upper hand in the Holy Roman Empire instead of the Habsburgs.
Wettin TL
Shortly after her birth (1242), Margaret was betrothed to Albert "the Degenerate", eldest son and heir of Henry III "the Illustrious", Margrave of Meissen. The marriage took place in June 1255, the bride receiving Pleissnerland (the towns of Altenburg, Zwickau, Chemnitz and Leisnig) as her dowry.
The couple settled at his residence in Eckartsberga and later moved to Wartburg, where she bore five children: three sons (Henry, Frederick and Dietzmann) and two daughters (Margaret and Agnes). Through her second son Frederick – later Margrave of Meissen – Margaret was the direct ancestor of the Electors and Kings of Saxony and English Queen consorts Margaret of Anjou and Anne of Cleves.
In 1265 her husband received the titles of Landgrave of Thuringia and Count Palatine of Saxony (German: Pfalzgräf von Sachsen) after the abdication of his father, who retained control of Meissen.
After the execution of her nephew Conradin (29 October 1268), Margaret, as the next legitimate relative, became the rightful Queen of Sicily and the general heiress of the Hohenstaufen claims over the Duchy of Swabia and the Kingdom of Jerusalem (despite the fact she was not descended from the Kings of Jerusalem, her father Frederick II had claimed the kingdom for himself). Her son Frederick assumed by some time this titles on her right.
The TL Diverges there
The schemes of Margaret of Sicily
On 1269, adultery of Albert the Degenerate was discovered by Margaret of Sicily and so he was not loyal to her and decided to devote herself on regaining the lands for her son.
Margaret of Sicily told her sons to gain her land, her first son Henry would be the one who will get her claims to Swabia and it will be Frederick who will get back Sicily and Naples.
The sons would quite object about the sudden change of character of their mother, and they would question her and told her, why would we want to regain the lands of our ancestor.
Margaret of Sicily would respond and told her sons that it is their rightful inheritance, she regains the control of Swabia with the help of her eldest son, Henry, one of the irritants is Rudolf of Habsburg who gained estates in Swabia whom they defeated in order to regain Swabia.
A few months after the defeat of Rudolf of Habsburg Margaret married his eldest daughter, Matilda to Henry of Meissen, her son, in order to get help to regain Swabia completely, Henry of Meissen, the Duke of Swabia revoked the Habsburg estates which forced the sons of Rudolf to Priesthood[1].
For Frederick of Meissen, he would marry Elisabeth of Hungary in order to ally with Hungary and protect them against the Premyslids and also to gain their help in regaining the Imperial crown for their lineage.
For the last son, Theodoric, the betrothal would be with the daughter of Gertrude of Babenberg, and the sister of Frederick of Baden, namely, Agnes of Baden.
For her daughters she is dreaming that Agnes of Meissen, she would marry a French Prince and Margaret of Meissen would marry a Polish duke, she was busy imagining the future for her own daughters as she told her servant, for the marriage of her daughter, Margaret, it would be the Kingdom of Arles that will be given to the French Prince as the dowry.
Her servant told her that she is too ambitious just because she was able to marry and betroth her sons and ensure that they will have future.
1. One of the sons of Rudolf Habsburg becomes the pope, the initial Habsburg lands go to the Wettins, what Margaret did was to eliminate the Habsburgs as a possible threat.