Edward IV's marriage to Elizabeth Woodville was personal slap in the face to Warwick since it came as he was negiotating the marriage agreement for Bonne of Savoy. Basically Warwick was made to look like either a fool or two-faced to the Savoyiards and French, which back then was unacceptable for any gentleman and along with being pushed out in favor of the lowly born Woodvilles made Warwick pissed since he basically put Edward on the throne.
So if the marriage to Bonne does take place, Edward and Warwick remain on good terms. However, Edward wasn't going to be under Warwick's thumb forever and would start going his own way on things, it was going to happen no matter what. Warwick's advice would still be held in high regard by Edward, if not always followed, and the chances are Warwick wouldn't be offended as in OTL because if he was smart he'd realize it was bound to happen because Edward IV wasn't Henry VI.
Without the Woodvilles getting influence because of Elizabeth's marriage to Edward, then its highly probable the George doesn't desert his brother for Henry VI and the Lancastrians before returning to his brother over his father-in-law Warwick. I say this because George would probably be given some influence by Edward since there were no Woodvilles that his wife would suggest. Since Richard was always loyal to his older brother and as a result Edward trusted him with the North, I don't see that changing.
Without Warwick and George seizing England and returning Henry VI to the throne, the Lancastrians remain in exile for the forseeable future.
If Edward IV dies with a minority heir then probably the a council will be formed headed by George, Richard, and Warwick (if he's still alive). Neither George or Richard will attempt to seize the throne because the other would oppose them and across the Channel in France would be the Lancastrian claimant Edward of Westminster, probably styling himself the true Edward IV.
Just my thoughts.