@noturaveragejoe0316 I actually think there's a good chance that John of Asturias' poor constitution will kill him before his wife has a chance to give him any children, just as it did OTL. I'm also tempted to say Isabella the Younger still dies young in childbirth, but in her case I'd much rather see her successfully deliver an heir to the Portuguese throne... who, with the death of her older brother, stands to inherit her parent's combined thrones as well. (UNIFIED IBERIA!) I also think Edward V and his Queen Joanna would eventually have a "cooling off" period, as far as the number of children go, though I've got no issue with the oldest five names (at the very least, I'd think Joanna would want a break after the twins).
Actually, on the subject of "cooling off" periods, that brings me to something else that struck me -- it seems a few people here think that Emperor Maximillian and Elizabeth of York would breed like rabbits if given the chance, having something like 11 kids between them, despite said Emperor already having an heir and a daughter by previous marriage; this is to say nothing of the fact that OTL, Max's latter two marriages were childless, or that OTL's Elizabeth of York only saw three of her children survive to adulthood. So while it's fair to say that they'd manage at least one son (or extra son, in the case of Max) between them, I don't expect they'd be too "busy" otherwise -- maybe Ernst has two sisters (at least who survive to adulthood with him), but I expect that'd be the extent of it.
At least that's my impression.