Vladislaus II of Hungary has healthy son and disabled daughter

Simply: reverse of OTL situation happens-in 1503 Queen Anne gives birth to a healthly son, in 1506 she dies giving birth to a daughter, who due to difficutlies at birth (hypoxia) is retarded. What impact would that change have?
Vladislaus' firstborn is healthly son, so there are less concerns about succession, especially among anti-Habsburg national party, whose leaders were Zapolyas. IOTL birth of Anna caused conflict between Vladislaus and Zapolya, King promised to HRE Maximilian that Anna would marry his grandson, at the same time promising to Zapolya that she would not marry Habsburg prince (nothing unusual for rex bene).
With Jagiellon succession in Hungary being more secure following changes would happen:
-Janos Zapolya, instead of trying to get hand of Vladislaus' daughter, who was outside his reach, marries Vladislaus' Hohenzollern niece instead (Margaret of Ansbach) as was planned.
-Sigismund the Old would likely not marry Barbara Zapolya in such case. IOTL Sigismund, who had bad relations with Habsburga before First Congress of Vienna in 1515, due to their support for Teutonic Order, was concerned about possibility of Habsburg succession in Hungary, with only retarded Louis between Habsburgs and Hungarian throne, thus to strenghten position of Janos Zapolya-leader of anti-Habsburg party, he married his sister. ITTL that is not necessary, especially if Janos Zapolya is already married to half-Jagiellon girl. That means another wife for Sigismund, possibly Catherine of Mecklenburg, whom he planned to marry before Barbara. That would have interesting consequences, taking into account Catherine's Protestant leanings.
-For Habsburgs something like OTL deal made in Vienna in 1515 would be less favorable. Their succession in Bohemia and Hungary is less likely than IOTL, and if Anna of Bohemia and Hungary is female version of OTL Louis II perspective of marriage with her would not make Ferdinand happy...
-Louis II being 13 instead of 10 at the time of father's death means, that degenerate Georg Hohenzollern has less time to "raise" his Jagiellon cousin.
-Even under sane Louis II Kingdom of Hungary can't resist Ottomans. So either Louis would try diplomatic means to save Hungary or some crushing defeat would still happen.
 
Simply: reverse of OTL situation happens-in 1503 Queen Anne gives birth to a healthly son, in 1506 she dies giving birth to a daughter, who due to difficutlies at birth (hypoxia) is retarded. What impact would that change have?
Vladislaus' firstborn is healthly son, so there are less concerns about succession, especially among anti-Habsburg national party, whose leaders were Zapolyas. IOTL birth of Anna caused conflict between Vladislaus and Zapolya, King promised to HRE Maximilian that Anna would marry his grandson, at the same time promising to Zapolya that she would not marry Habsburg prince (nothing unusual for rex bene).
With Jagiellon succession in Hungary being more secure following changes would happen:
-Janos Zapolya, instead of trying to get hand of Vladislaus' daughter, who was outside his reach, marries Vladislaus' Hohenzollern niece instead (Margaret of Ansbach) as was planned.
-Sigismund the Old would likely not marry Barbara Zapolya in such case. IOTL Sigismund, who had bad relations with Habsburga before First Congress of Vienna in 1515, due to their support for Teutonic Order, was concerned about possibility of Habsburg succession in Hungary, with only retarded Louis between Habsburgs and Hungarian throne, thus to strenghten position of Janos Zapolya-leader of anti-Habsburg party, he married his sister. ITTL that is not necessary, especially if Janos Zapolya is already married to half-Jagiellon girl. That means another wife for Sigismund, possibly Catherine of Mecklenburg, whom he planned to marry before Barbara. That would have interesting consequences, taking into account Catherine's Protestant leanings.
-For Habsburgs something like OTL deal made in Vienna in 1515 would be less favorable. Their succession in Bohemia and Hungary is less likely than IOTL, and if Anna of Bohemia and Hungary is female version of OTL Louis II perspective of marriage with her would not make Ferdinand happy...
-Louis II being 13 instead of 10 at the time of father's death means, that degenerate Georg Hohenzollern has less time to "raise" his Jagiellon cousin.
-Even under sane Louis II Kingdom of Hungary can't resist Ottomans. So either Louis would try diplomatic means to save Hungary or some crushing defeat would still happen.
Keep Ferdinand of Aragon alive for another couple of years and Ferdinand jr will be unavailable for Anna (who will marry Maximilian as fourth wife here)
 
Keep Ferdinand of Aragon alive for another couple of years and Ferdinand jr will be unavailable for Anna (who will marry Maximilian as fourth wife here)
Wouldn't Anna marry Charles in such case? Max was not willing to remarry (he had another goal late in life-he wanted to became Pope).
 
Wouldn't Anna marry Charles in such case? Max was not willing to remarry (he had another goal late in life-he wanted to became Pope).
No. Charles had already said who he had zero intention to marry Anna and Ferdinand was under the guardianship of the other grandfather so Max promised to marry Anna himself if neither grandson would be available for her in a year. Then Ferdinand of Aragon died and Ferdinand was shipped to Austria and engaged to Anna. Charles was interested only in matches useful for Burgundy (and was engaged to many English/French princesses before he resigned himself to listen his Cortes and married Isabella of Portugal who had already rejected at least twice).... Plus Charles was forced to give the whole Austrian inheritance to Ferdinand (instead of only a part) for making him a worthy husband for Anna...
 
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