The War of the League of Cambrai was intended to dismember Venice's European possessions and divide them up amongst the victors. So let's say that happens, when Venice loses the war. Austria gets Istria and much of Friuli. France-backed Milan gets the far western part of the territory, and the Papal States would get Ravenna. the Republic was to be reduced basically to the city of Venice and its Mediterranean holdings.
What impact would this have on Venice? Would it break them fully, a blow they would never recover fom? Or could the lack of territory in Europe remove distraction from Venice and allow them to prosper again? What do you think the effects of a Venetian loss would be?