Variola Minor instead of Major in the Aztec Empire first?

Forgive me if this question lacks good medical sense but my knowledge is limited on the subject. I was wondering in relation to the Spanish conquest of the Aztec Empire if they could have transmitted just Variola Minor of the smallpox plague first? Would this have immunized a portion of the Aztec Empire? Does this even make sense medically? Would being minor or major even matter if the population had no immunity?
 
IIRC it was first documented in America but probably evolved in Africa. Though no one knows for sure, it's speculated to originate in the 19th century.

If something like it evolved earlier it would compete with variola major and a lot of people would have survived, changing history everywhere. Smallpox killed thousands in Europe every year. If it evolved in isolation in the Americas or Americas and SS Africa then it would greatly reduce death from variola major introduced by the Spanish. Though there were a multitude of diseases in the Atlantic Exchange, many just as deadly.

Variola minor killed less than 1% of those infected. In virgin soil situation it might be worse, but fatality would probably still be low as the morbidity of the disease is low to begin with (the infected didn't get terribly sick). The vast majority of natives would still die from other diseases, but it would slow Spanish conquests. Some areas may not be conquered, and the native population would be more numerous today, with some extinct tribes still in existence.
 
It would not slow the Spanish conquest of the Aztecs. The Spanish basically asked around "Hey, we're going to kick Aztec butt. Want to be our subordinates" and so many factions gave up the status quo and (somewhat knowingly) allowed the Spanish to be the dominant partner and send missionaries to convert their people. So basically, instead of a -99% population, we might be looking at a -25% (virgin soil instead of exposed population), but that means more allies for the Spanish. Unless the extra people mean the land can't support the Spanish and their (more numerous) allies, I don't see why they can't still win.
 
http://m.pnas.org/content/104/40/15787.full

Another primary clade included both alastrim minor, a phenotypically mild smallpox described from the American continents, and isolates from West Africa. This clade diverged from an ancestral VARV either 1,400 or 6,300 YBP, and then further diverged into two subclades at least 800 YBP.
YBP = Years Before Present

Ah, so the minor form existed plenty early enough. Maybe wouldn't changed everything, but would have changed a hell of a lot.
 
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